1-[4-(4-aminophenyl)-1-piperazinyl]ethanone

The chemical name **1-[4-(4-aminophenyl)-1-piperazinyl]ethanone** refers to a compound that is commonly known as **N-(4-aminophenyl)piperazine-1-ethanone** or **PAE**.

**Structure and Properties:**

* **PAE** is an organic compound that contains a piperazine ring, an amide group, and an aniline moiety.
* It is a white to off-white solid that is soluble in organic solvents.

**Importance in Research:**

**1. Potential Therapeutic Applications:**

* **Antidepressant activity:** PAE has shown promising antidepressant activity in preclinical studies. It is believed to act as a serotonin and dopamine reuptake inhibitor, similar to other antidepressant medications.
* **Anti-inflammatory activity:** PAE has also demonstrated anti-inflammatory properties in animal models of inflammation. Its mechanism of action may involve modulation of inflammatory signaling pathways.
* **Analgesic activity:** Some studies suggest that PAE may possess analgesic properties, potentially by interfering with pain signaling pathways.

**2. Chemical and Biological Probe:**

* **Synthetic building block:** PAE is a versatile building block for the synthesis of other bioactive compounds. Its functional groups can be modified to create novel molecules with different pharmacological properties.
* **Tool for studying biological targets:** PAE can be used as a tool to study the binding properties and pharmacological effects of specific receptors or enzymes.

**3. Research into Piperazine Derivatives:**

* **Structure-activity relationship studies:** PAE serves as a lead compound for investigating the structure-activity relationship of piperazine derivatives. By modifying its chemical structure, researchers can explore the effects of different functional groups on pharmacological activity.
* **Development of new drugs:** PAE provides a starting point for the development of new drugs targeting various disease conditions.

**Important Note:**

While PAE shows potential therapeutic benefits, it is still in the early stages of research. Extensive preclinical and clinical studies are necessary to determine its safety and efficacy before it can be considered for human use.

**Disclaimer:** I am an AI chatbot and cannot provide medical advice. If you have any questions or concerns about specific medical conditions or treatments, please consult a qualified healthcare professional.